DNA strand asymmetry
نویسندگان
چکیده
منابع مشابه
Bacterial DNA strand compositional asymmetry: response.
T he main point of this response is to state the primary aim of our paper 1 : our purpose was not to develop yet another method of locating the oriC site based on the GC bias (there are already many excellent methods for this) but to study the effect of this bias on genes. The comparison of our approach with the GC-skew plot, or related techniques, is therefore inappropriate – how can a skew pl...
متن کاملDNA Replication and Strand Asymmetry in Prokaryotic and Mitochondrial Genomes
Different patterns of strand asymmetry have been documented in a variety of prokaryotic genomes as well as mitochondrial genomes. Because different replication mechanisms often lead to different patterns of strand asymmetry, much can be learned of replication mechanisms by examining strand asymmetry. Here I summarize the diverse patterns of strand asymmetry among different taxonomic groups to s...
متن کاملBifractality of human DNA strand-asymmetry profiles results from transcription.
We use the wavelet transform modulus maxima method to investigate the multifractal properties of strand-asymmetry DNA walk profiles in the human genome. This study reveals the bifractal nature of these profiles, which involve two competing scale-invariant (up to repeat-masked distances less, or similar 40 kbp) components characterized by Hölder exponents h{1}=0.78 and h{2}=1, respectively. The ...
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The activation-induced cytidine deaminase (AID) is required for somatic hypermutation (SHM) and class-switch recombination (CSR) of immunoglobulin (Ig) genes, both of which are associated with DNA double-strand breaks (DSBs). As AID is capable of deaminating deoxy-cytidine (dC) to deoxy-uracil (dU), it might induce nicks (single strand DNA breaks) and also DNA DSBs via a U-DNA glycosylase-media...
متن کاملThe study of dose gamma rays of 192Ir source on DNA single strand break (SSB) and DNA double strand break (DSB) in soft tissue phantom
Introduction: Passage of ionizing radiation through the organs of living creatures develops clusters of damaged nucleotides inside the DNA rounds. 192Ir Gamma source is one of the most widely used sources in brachytherapy of cervical and prostate cancer. Thus, in this research, we investigated the flux of photons and its resulting secondary electrons, the single-strand break (S...
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ژورنال
عنوان ژورنال: Nature
سال: 1991
ISSN: 0028-0836,1476-4687
DOI: 10.1038/352114b0